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mutations and complicated kar yotype. It follows a linear evolution from your CLL clone with the recurrent acquisition of CDKN2A
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Not all patients with CLL require therapy. Even with all current innovations, the iwCLL nevertheless suggests watchful observation for sufferers with asymptomatic illness.86 This advice is predicated on no less than two randomized trials comparing observation to both chlorambucil monotherapy or fludarabine, cyclophosphamide and rituximab (FCR).103,104 Both equally trials concluded that early therapy in asymptomatic individuals was not linked to a chronic Over-all survival.
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